Do you have the color space set to sRGB in both programs?

Check the monitor profile PSE and NC are loading. These are the only apps
with color management, which would make use of it. Also check the working
color space as well.

[...]

It sounds like your colour profile has gotten screwed up, or that you
perhaps have more than one program trying to run your colour
management.
I can't think of anything specific, unfortunately, because there's a
bunch of places where this could be going wrong. I'd try looking at
the following:
1: Make that Adobe Gamma is disabled/removed (check in your Control
Panel)
2: Open the Optivision tool for your Spyder & check to see if the
"Calibration Enabled" checkbox is ticked, then see which profile is
selected.
3: Look in "Display Properties", then "Colour Management" for your
cololur profile. Removing it *should* make your colour-managed app's
look the same as your normal Windows app's. If the problem remains,
it's likely that Adobe Gamma or another colour-management tool is
running things.
4: You might try uninstalling your video card drivers, rebooting, then
reinstalling them (download the latest versions if you're running
older versions). This is a bit of a long shot, but it could be the
cure if your drivers or config are corrupted.

Best of luck, & please let us know what kind of results you get.